Program
Printable Version of Program
TENTATIVE PROGRAM - Program subject to change
Sunday, March 7, 2010
1:00 pm - Registration Desk Open
3:00 pm - Welcome Address - Magdi H. Yacoub and Ajit P. Yoganathan
Session I – Young Investigator Awards
Session Chairs: Robert Nerem and Magdi Yacoub
3:10 pm - Choon Hwai Yap - In Vitro Measurement of Fluid Shear Stresses on the Aortic Valve Leaflet
3:30 pm - Krista L. Sider - Local Valve Matrix Stiffness and Its Effect on Valve Interstitial Cell Differentiation
3:50 pm - Elizabeth H. Stephens - Functional Coupling of Valvular Interstitial Cells and Collagen in the Mitral Leaflet
4:10 pm - Nicholas Amoroso - Fabrication Techniques for Electrospun Polyeurthane Scaffolds that Generate Valve Leaflet Mechanical Properties
4:30 pm - Jan-Hung Chen - Beta-catenin mediates mechanically-regulated, TGF-beta1-induced valve interstitial cell myofibrogenesis
4:50 pm - Ismail El-Hamamsy - Differential Pro-Calcification Potential of Aortic versus Ventricular Aspects of the Aortic Valve Endothelium
5:10 pm - Break
5:30 pm - Special Lecture - Ajit Yoganathan - The Future of Heart Valve Research: From Engineering to Biology
Monday, March 8, 2010
Session II – Valve mechanics/mechanobiology
Session Chairs: Michael Sacks and Ulrich Stock
8:00 am - Keynote Speaker – Craig Simmons - Mechanobiology of valve stem cells and calcific aortic valve disease
8:30 am - Jennifer Richards - Valvular Endothelial Cells Mitigate Interstitial Cell Activation and Calcification in Mechanically Stressed 3D Matrix Environments
8:45 am - Kartik Balachandran - Elevated Serotonin Levels Result in Increased Collagen Biosynthesis via the 5HT2A Receptor in Stretch-Overloaded Aortic Valves
9:00 am - Scott A. Metzler - Cyclic Strain Activates Aortic Valve Endothelial Cells in a Side-Specific Manner
9:15 am - Randall F. Ankeny - Bone Morphogenic Protein Pathway Activation in Sclerotic Human Aortic Valves
9:30 am - Varun K. Krishnamurthy - Regional Aortic Valve Biomechanics in a Mouse Model of Aortic Valve Disease
9:45 am - Alessandro Borghi - Contributions of GAGs to the Biomechanics of the Aortic Valve
10:00 am - Coffee Break
Session III – Mitral and Tricuspid valves from structure to function
Session Chairs: Elena Aikawa and Ajit Yoganathan
10:30 am - Keynote Speaker - K. Jane Grande-Allen - Heterogeneity of Cell Phenotypes, Extracellular Matrix, and Tissue Function in the Mitral Valve
11:00 am - Julia C. Swanson - Multiple Mitral Valve Leaflet Contractile Systems in the Beating Heart
11:15 am - Erin Spinner - Annular Dilatation and Papillary Muscle Displacement Significantly Increase Tricuspid Regurgitation: An in vitro Study
11:30 am - Muralidhar Padala - Novel Posterior Leaflet Reshaping to Relieve Sub-valvular Tethering in Ishemic Mitral Regurgitation
11:45 am - Jesper Brink Askov - New Miniature Chordal Force Transducer for Measurements In Vivo
12:00 pm – Break for Lunch
Session IV – Pathogenesis of Valve Disease
Session Chairs: Jonathan Butcher and Adrian Chester
1:30 pm – Keynote Speaker - Hervé Le Marec - Genetics: a new approach for the understanding of valvular diseases
2:00 pm - James N. Warnock - Elevated Pressure Modulates Osteogenic De-Differentiation of Aortic Valve Interstitial Cells
2:15 pm - Jacqueline D Peacock - Reduced Sox9 function promotes heart valve calcification phenotypes
2:30 pm - Elaine E. Wirrig - Sequential Osteogenic Gene Induction in Human and Mouse Aortic Valve Disease
2:45 pm - Kristyn S. Masters - Role of the Rho Pathway in Valve Calcification
3:00 pm - Zannatul Ferdous - Utilizing tissue-engineered models to investigate vascular and valvular calcification
3:15 pm - Cindy Y.Y. Yip - C-type natriuretic peptide suppresses pathological differentiation of valve interstitial cells
3:30 PM - Adjourn
6:30 PM - Poster Session
Tuesday, March 9, 2010
Session V – Cell & Matrix Biology - Structure and Function
Session Chairs: K. Jane Grande-Allen and Hanjoong Jo
8:00 am – Keynote Speaker - Frank Baaijens, Ph.D. - Heart valve tissue engineering
8:30 am - Francesca Colazzo - Extracellular Matrix Production By Adipose–Derived Stem Cells: Implications For Heart Valve Tissue Engineering
8:45 am - Michael Sacks - Matrix synthesis and cellular deformations of cells in engineered heart valve scaffolds
9:00 am - Morakot Likhitpanichkul - Marked differences in myofibroblast differentiation potential of layer-specific aortic valve interstitial cells
9:15 am - W. David Merryman - 5-HT2b antagonist prevents TGF-beta1-mediated activation of AVICs, potentially via Src tyrosine kinase
9:30 am - Peggi M. Angel - Functional Organization of Valvular Subanatomy by Proteomics and MALDI Imaging Mass Spectrometry
9:45 am - Huan Wang - Global effects of TGF-beta1 on porcine valvular interstitial cells
10:00 am - Coffee Break
Session VI – Biomaterials and Tissue Engineering
Session Chairs: Frank Baiijens and Patricia Taylor
10:30 am - Keynote Speaker - Abhay Pandit, Ph.D. - Designing Functionalised Biomaterials Platforms
11:00 am - Laura Ann Hockaday - Custom 3D Heterogeneous Microenvironments for Valve Tissue Engineering
11:15 am - Robert Tranquillo - Implantation of a Human Tissue-engineered Heart Valve Exhibiting Short-term Function in the Sheep Pulmonary Artery
11:30 am - Lindsay Mesure - Development and evaluation of self-recellularizing material for cardiovascular prostheses
11:45 am - Ivan Carubelli - Development of collagen based scaffolds for tissue engineering aortic valves
12:00 pm – Break for lunch
Session VII - Translation to the Clinic
Session Chairs: Simon Hoerstrup and Hanneke Takkenberg
1:30 pm – Keynote Speaker - Volkmar Falk, M.D. - Transapical aortic Valve Implantation – Patient selection, Imaging, Results and Future directions
2:00 pm - Magdi Yacoub - Late Aortic Root Biomechanics Following the Ross Procedure
2:15 pm - Benedikt Weber - Minimally Invasive Implantation of Autologous Tissue Engineered Heart Valves
2:30 pm - Francis Robicsek, MD PhD - The First Experiments in Heart Valve Transplantation
2:45 pm - Al Heacox - CryoValve® SG Antigen-Reduced Human Pulmonary Heart Valves – Pre-clinical and Clinical Evaluations
3:00 pm - Georg Lutter - Transapical implantation of novel mitral valved stent: short-term survival
3:15 pm - Anja Metzner - Percutaneous pulmonary valve replacement: use of autologous tissue engineered valved stents
3:30 pm - Adjourn
6:30 pm - Meeting Reception and Dinner
Wednesday, March 10, 2010 - Developmental Biology Symposium
Morning Session Chairs: Roger Markwald and Magdi Yacoub
8:30 am - Bob Nerem: Introductory Comments
8:35 am - Keynote Speaker - José Luis de la Pompa - Concerted activity of Notch and BMP2 during cardiac valve development
9:20 am - Zoltan Hajdu - Fibroblasts of hematopoietic orgin contribute to embryonic heart valve development
9:35 am - Derek H. Rosenzweig - Scleraxis regulation of collagen type XIV during embryonic heart valve remodeling
9:50 am - Coffee Break
Session on Developmental Biology of the Heart Valve
10:15 am - Invited Speaker - Mark Mercola - Discovery of Small Molecules for Myocardial Differentiation
11:00 am - Katherine E. Yutzey - Wnt signaling in heart valve development and osteogenic gene induction
11:15 am - Philip Buskoh - Effect of TGF-beta and Serotonin on Mechanical Properties of Embryonic Atrioventricular Valves
11:30 am - Break for Lunch
Session on the Developmental Biology of the Heart
Afternoon Session Chairs: Adrian Chester and Robert Nerem
1:00 pm – Keynote Speaker – David Peal - Using Zebrafish to Study the Role of Proteoglycans in Mitral Valve Development
1:45 pm - Richard Visconti - Bone marrow contribution to heart valve remodeling in response to myocardial infarction
2:00 pm - Jonathan Butcher - Non-invasive Femtosecond-laser Photoablation of Embryonic Outflow Tract:Microsurgical Congenital Heart Defects Models
2:15 pm - Invited Speaker - Roger Markwald - Developmental Mechanisms of Adult Cardiovascular Remodeling Diseases: Valvular Heart Diseases (VHD)
